Producción Científica

Asthma is a heterogeneous inflammatory disorder involving multiple immune pathways, frequently presenting alongside comorbidities such as chronic rhinosinusitis with nasal polyps (CRSwNP). Although biologic therapies such as dupilumab have shown clinical efficacy, the molecular mechanisms underlying variable treatment responses remain poorly understood. This study aimed to characterize transcriptomic patterns that distinguish asthmatic patients from healthy controls and to evaluate...

CONCLUSIONS: HRQL of people with FA is impaired by multiple determinants that should be addressed through psychosocial support, dietary management and education. Being female was the determinant with the highest negative impact, and adult women with multiple FAs have the poorest FA-HRQL and require targeted personalised interventions.

CONCLUSION: This work proposes a harmonized, scalable approach for cataloging imaging biomarkers. Consistent descriptors across contexts facilitate integration into research, regulatory, and clinical workflows.

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Current therapies for osteoarthritis (OA) focus on symptom management, rather than halting disease progression. Vasoactive intestinal peptide (VIP) has shown promising effects in musculoskeletal diseases, preserving joint integrity and modulating inflammation. This study investigates the potential of VIP to promote chondrogenic differentiation of human bone marrow mesenchymal stem cells (BM-hMSC) and to modulate inflammatory and cartilage extracellular matrix (ECM)-degrading mediators in human...

CONCLUSION: This study reveals sex-dependent variation in C4 CN as a novel genetic risk factor for GCA and IgAV, suggesting shared biologic mechanisms involving complement dysregulation, sustained inflammation, and vascular damage.

OBJECTIVE: This study aimed to 1) develop and test the reliability of a semiquantitative ultrasound score to assess muscle quality in patients with rheumatoid arthritis (RA), and 2) evaluate how incorrect adjustments of ultrasound settings affect muscle quality assessment. METHODS: The Spanish Ultrasound Muscle Assessment in RA (SpUMAR) Score consisted of a semiquantitative 0–3 score based on the degree of loss of the normal muscle ultrasound pattern that was agreed upon by 15 rheumatologists...

Multiple sclerosis (MS) is a heterogeneous inflammatory disease of the central nervous system in which environmental factors, particularly viral infections, are thought to contribute to disease susceptibility and progression. However, whether antiviral immune responses differ across clinical phenotypes remains incompletely understood. In this study, we analyzed the distribution of antiviral serology in patients with primary progressive, relapsing–remitting, and secondary progressive MS,...

Monocytes and monocyte-derived macrophages play a key pathogenic role in inflammatory arthritis. Methotrexate (MTX) is the first-line disease-modifying antirheumatic drug (DMARD) for arthritis, yet the mechanisms and kinetics of its effects on monocyte/macrophages remain poorly understood. We have now investigated the temporal dynamics of the MTX's anti-inflammatory action by initially performing a phase I clinical trial (METOMAC) on healthy individuals following a single MTX dose, which...

CONCLUSION: Multiomic profiling delineates molecular endotypes in SLE, integrating immune, vascular, and metabolic pathways associated with CV risk and LN, supporting their potential for precision risk stratification.